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Biochem Biophys Res Commun. 1998 Jul 9;248(1):115-20.

The localization of the site of arylalkylamine N-acetyltransferase circadian expression in the photoreceptor cells of mammalian retina.

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  • 1National Institute of Bioscience and Human Technology, Agency of Industrial Science and Technology, MITI, Ibaraki, Japan.

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  • Biochem Biophys Res Commun 1999 Aug 2;261(2):546.

Abstract

To investigate the molecular mechanism of the melatonin rhythm in the mammalian retina, we examined the temporal mRNA expression pattern of arylalkylamine (serotonin) N-acetyltransferase (AA-NAT), the rate-limiting enzyme in melatonin synthesis in the rat retina. Rat AA-NAT mRNA was detected exclusively in the retinal photoreceptors in the outer nuclear layer--low during the day and increased more than threefold at night. The nocturnal AA-NAT expression in rat retina was also confirmed by RNase protection and the AA-NAT enzymatic activity. This is the first report to localize the site of AA-NAT mRNA circadian expression in mammalian photoreceptor cells.

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