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FEMS Microbiol Lett. 1998 Jun 15;163(2):223-8.

On the origin of membrane vesicles in gram-negative bacteria.

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Department of Microbiology and Immunology, University of Louisville, KY 40292, USA.


It is proposed that the genesis of extracellular membrane vesicles in Gram-negative bacteria is a result of cell wall turnover. Peptidoglycan turnover would cause a turgor on the outer membrane, causing the outer membrane to bulge and finally bleb. Mechanical motion would then shear the blebs into the culture medium.

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