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Microsc Res Tech. 1998 Jun 1;41(5):372-8.

Role of Oct-6 in Schwann cell differentiation.

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1
Department of Cell Biology and Genetics, Erasmus University Rotterdam, The Netherlands.

Abstract

Research into the POU transcription factor Oct-6 has been the focus of much current attention, in particular its role in Schwann cell development and differentiation. Based on published data and data presented here, we propose a model for Oct-6 function at two distinct stages of Schwann cell maturation. First, Oct-6 function is required in promyelin cells for their timely differentiation into myelinating cells. Second, Oct-6 functions during myelination and is required for the proper downregulation of its own gene. While the first function of Oct-6 is firmly established, the second function is still highly hypothetical. Experiments to establish a distinct role for Oct-6 in late Schwann cell differentiation are discussed.

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