Format

Send to

Choose Destination
See comment in PubMed Commons below
Oncogene. 1998 Jul 9;17(1):123-7.

Allelic loss of chromosome 10q23 is associated with tumor progression in breast carcinomas.

Author information

1
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

Abstract

To determine the status of chromosome 10q23 in primary breast carcinomas, in situ and invasive carcinomas were analysed for allelic loss using microsatellite markers spanning the 10q23 region. No LOH was seen in pure intraductal carcinomas (0/20 cases). On the other hand, LOH was observed in 40% (17/42) of invasive carcinomas (P = 0.0005). Interestingly, in situ lesions found in invasive tumors displayed LOH. Allelic loss was also significantly associated with loss of the estrogen receptor (P = 0.011). Thus, loss of the 10q23 is strongly associated with tumor progression.

PMID:
9671321
DOI:
10.1038/sj.onc.1201940
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center