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Endocrinol Metab Clin North Am. 1998 Jun;27(2):465-83.

The science and therapy of glucocorticoid-induced bone loss.

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Division of Rheumatology, University of California at San Francisco, USA.


Glucocorticoids are critical in the management of chronic, noninfectious, inflammatory diseases. Bone loss is a most devastating side effect of these powerful medications. Glucocorticoids produce bone loss by altering calcium metabolism, suppressing gonadal hormone production, and inhibiting bone formation. Now that the mechanism of glucocorticoid-induced bone loss is understood and effective medications are available, this disease can be prevented and reversed.

[Indexed for MEDLINE]

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