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Curr Opin Chem Biol. 1998 Apr;2(2):269-78.

Substrate binding and catalysis in heme peroxidases.

Author information

1
School of Biological Sciences, University of Sussex, Brighton, BN1 9QG, UK. a.t.smith@sussex.ac.uk

Abstract

Peroxidase-catalysed reactions are being analysed at an increasingly advanced level of structural and mechanistic sophistication. A significant development in this respect has been the long-anticipated solution of crystal structures for several plant peroxidases and a fungal peroxidase complexed to benzhydroxamic acid. New insights into peroxide binding and catalysis have been obtained through site-directed mutagenesis, a technique also crucial to recent progress in understanding the diversity of substrate interaction sites associated with peroxidases from different sources.

PMID:
9667928
[Indexed for MEDLINE]

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