Format

Send to

Choose Destination
Curr Opin Chem Biol. 1997 Dec;1(4):543-51.

Biosynthetic systems for nonribosomal peptide antibiotic assembly.

Author information

1
Philipps-Universit├Ąt Marburg, Fachbereich Chemie/Biochemie, Hans-Meerwein-Strasse 35032, Marburg, Germany.

Abstract

Modular peptide synthetases, which act as the protein templates for the synthesis of a large number of peptide antibiotics and siderophores, hold great potential for the development of novel compounds. Recently, significant progress has been made towards understanding their molecular architecture and substrate specificity. The first crystal structure of a peptide synthetase has been solved, and the enzymes responsible for post-translational modification of peptide synthetases have recently been discovered. These will allow addressing important yet poorly understood mechanistic aspects.

PMID:
9667890
DOI:
10.1016/s1367-5931(97)80051-8
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center