Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Chem Biol. 1997 Aug;1(2):210-8.

Controlling mammalian gene expression with small molecules.

Author information

ARIAD Gene Therapeutics, 26 Landsdowne Street, Cambridge, MA 02139, USA.


Several systems are now available that enable transcription of a gene introduced into mammalian cells to be controlled using small molecules. Among the potential applications are the analysis of gene function through creation of inducible alleles in cell culture and transgenic animals, and, ultimately, the pharmacological control of therapeutic protein production in vivo in the context of gene therapy. Highlights of the past year include several demonstrations of regulated protein production in animal models of gene and cell therapy, and the development of a new approach to transcriptional regulation using chemical inducers of dimerization.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center