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Curr Opin Chem Biol. 1997 Jun;1(1):47-53.

Synthetic strategies in combinatorial chemistry.

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Department of Chemistry, University of California, Berkeley, California, 94720-1460, USA.


Different synthetic strategies are required for the two kinds of libraries being developed for combinatoral chemistry. Preparation of a 'focused' library involves conversion of a known synthetic route to the solid-phase or automated format, whereas generation of a 'prospecting' library is driven more by availability of input materials and considerations of structural novelty. While both types can be identified over the history of combinatorial chemistry, elaborating syntheses of novel, nonoligomeric, 'drug-like' molecules for use in prospecting libraries is a relatively recent development.

[Indexed for MEDLINE]

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