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Curr Opin Chem Biol. 1997 Jun;1(1):60-6.

Encoding methods for combinatorial chemistry.

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  • 1IRORI Quantum Microchemistry, 11025 North Torrey Pines Road, La Jolla, CA 92037-1030, USA.


Assuming that the chemical reactions used to synthesize a combinatorial library member are successful, then knowledge of the specific reaction sequence is equivalent to knowing the member's chemical identity. Because the determination of chemical identity is typically not automatable and requires a substantial amount of material, schemes that encode a member's reaction history onto the reaction platform are of value. The primary benefits of encoding are relational nomenclature (all methods) and automated handling (some methods). Encoding methods evaluated to date are spatial, graphical, chemical, spectrometric, electronic, and physical.

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