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Vision Res. 1998 May;38(10):1517-24.

Prolonged administration of NT-4/5 fails to rescue most axotomized retinal ganglion cells in adult rats.

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Centre for Research in Neuroscience, Montreal General Hospital Research Institute, Qu├ębec, Canada.


The survival of axotomized RGCs was increased by intravitreal NT-4/5 given by repeated injections or osmotic minipumps, but the effects were less complete than predicted. Compared to a single injection of the neurotrophin on day 0, second injections on days 3 or 7 only sustained an additional 10-20% of the RGCs on day 10. Minipumps augmented RGC survival up to 4-fold (50%) at 2 weeks but most RGCs were lost by 1 month. Thus, specific neurotrophins can rescue many RGCs soon after injury but long-term neuronal survival may require a better understanding of changes in neurotrophin receptors and interactions with other molecules.

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