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Curr Opin Struct Biol. 1998 Jun;8(3):364-71.

Protein fold irregularities that hinder sequence analysis.

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SmithKline Beecham Pharmaceuticals, Bioinformatics, New Frontiers Science Park (North), Essex, UK.


The detection of homologous protein sequences frequently provides useful predictions of function and structure. Methods for homology searching have continued to improve, such that very distant evolutionary relationships can now be detected. Little attention has been paid, however, to the problems of detecting homology when domains are inserted or permuted. Here we review recent occurrences of these phenomena and discuss methods that permit their detection.

[Indexed for MEDLINE]

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