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Curr Opin Struct Biol. 1998 Jun;8(3):338-45.

Detection of internal repeats: how common are they?

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Division of Mathematical Biology, National Institute for Medical Research, London, UK.


The exponential growth in the amount of genomic data published in recent years has led to increased efforts in analysing genomes for the presence of repeated sequences, which has in turn fostered the development of novel repeat recognition methods. This has resulted in a deepened understanding of the importance and abundance of protein and nucleotide repeats. In the past year, a shift in focus has taken place--from the significance of repeats to protein structure and function, mostly at the protein domain level, to the implication of generally much shorter repeated fragments in genetic diseases and protein malfunctioning.

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