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Curr Opin Struct Biol. 1998 Jun;8(3):333-7.

Repeats in genomic DNA: mining and meaning.

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Genetic Information Research Institute, Sunnyvale, CA 94089, USA.


For hundreds of millions of years, perhaps from the very beginning of their evolutionary history, eukaryotic cells have been habitats and junkyards for countless generations of transposable elements, preserved in repetitive DNA sequences. Analysis of these sequences, combined with experimental research, reveals a history of complex 'intracellular ecosystems' of transposable elements that are inseparably associated with genomic evolution.

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