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J Mol Biol. 1998 Jul 17;280(3):323-6.

Homology-based fold predictions for Mycoplasma genitalium proteins.

Author information

1
EMBL, Max-Delbrück-Center for Molecular Medicine, Meyerhoftstr.1, Heidelberg, 69012, Germany.

Abstract

Homology search techniques based on the iterative PSI-BLAST method in combination with various filters for low sequence complexity are applied to assign folds to all Mycoplasma genitalium proteins. The resulting procedure (implemented as a web server) is able to predict at least one domain in 37% of these proteins automatically, with an estimated accuracy higher than 98%. Taking structural features such as coiled coil or transmembrane regions aside, folds can be assigned to more than half of the globular proteins in a bacterium just by iterative sequence comparison.

PMID:
9665839
DOI:
10.1006/jmbi.1998.1884
[Indexed for MEDLINE]
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