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Neuroreport. 1998 Jun 1;9(8):1723-6.

IL-10 down-regulates human microglial IL-8 by inhibition of NF-kappaB activation.

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1
Institute for Brain and Immune Disorders at the Minneapolis Medical Research Foundation, University of Minnesota Medical School, 55404, USA.

Abstract

In the present study, we tested the hypothesis that interleukin (IL)-10 down-regulates human microglial cell IL-8 release by inhibiting activation of nuclear factor kappa B (NF-kappaB). Immunohistochemical staining demonstrated that IL-10 markedly suppressed lipopolysaccharide (LPS)- and IL-1beta-stimulated IL-8 expression. NF-kappaB involvement was suggested by the finding that pyrrolidinedithiocarbamate, a known inhibitor of NF-kappaB activation, blocked LPS- and IL-1beta-induced IL-8 production. Consistent with our hypothesis, IL-10 treatment of LPS- and IL-1beta-stimulated microglia was associated with a marked decrease in NF-kappaB translocation from the cytoplasm to the nucleus.

[Indexed for MEDLINE]

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