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Nat Struct Biol. 1998 Jul;5(7):555-60.

The structure of mammalian hexokinase-1.

Author information

1
Department of Biochemistry, Michigan State University, East Lansing, USA. mulichak@alecto.bch.msu.edu

Abstract

We have determined the structures of the glucose-6-phosphate (G6P)-inhibitable 100,000 Mr Type I hexokinase from rat and the G6P-sensitive 50,000 Mr hexokinase from Schistosoma mansoni at a resolution of 2.8 and 2.6 A respectively. The structures define the glucose and G6P binding sites in these enzymes, suggest the mechanisms of intradomain G6P inhibition and activity loss in the Type I hexokinase N-terminal half, and reveal the structure of the membrane targeting motif that integrates the Type I hexokinase into the outer mitochondrial membrane.

PMID:
9665168
DOI:
10.1038/811
[Indexed for MEDLINE]

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