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Nature. 1998 Jul 2;394(6688):35-8.

G-protein diseases furnish a model for the turn-on switch.

Author information

1
Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143-0450, USA.

Abstract

How does a trimeric G protein on the inside of a cell membrane respond to activation by a transmembrane receptor? G-protein mutations in patients with hypertension and inherited endocrine disorders enhance or block signals from stimulated receptors. In combination with three-dimensional crystal structures and results from biochemical experiments, the phenotypes produced by these mutations suggest a model for the molecular activation mechanism that relays hormonal and sensory signals transmitted by many transmembrane receptors.

PMID:
9665125
DOI:
10.1038/27831
[Indexed for MEDLINE]

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