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Genes Cells. 1998 Apr;3(4):203-8.

Growth phase coupled modulation of Escherichia coli ribosomes.

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Department of Physics, Osaka Medical College, Takatsuki, Japan.


Ribosomal modulation factor (RMF), a small basic protein, expresses transcriptionally in the stationary phase of Escherichia coli cells and binds to 50S ribosomal subunits. The RMF bound 70S ribosomes dimerize to form 100S particles that have no translational activity. In transferring the stationary cells to a fresh medium, the 100S particles release the RMF and dissociate to active 70S. The interconversion of ribosomes between active 70S and inactive 100S by RMF is a cellular mechanism controlling translation.

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