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Am J Obstet Gynecol. 1998 Jun;178(6):1354-8.

Analysis of three hundred fifteen ectopic pregnancies treated with single-dose methotrexate.

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1
Department of Obstetrics and Gynecology, University of Tennessee, Memphis, USA.

Abstract

OBJECTIVES:

The objective of this study was to review the largest single series of ectopic pregnancies treated with single-dose methotrexate reported to date.

STUDY DESIGN:

A review of 315 patients with unruptured ectopic pregnancies treated with single-dose methotrexate 50 mg/m2 from March 21, 1990, to March 1, 1997, was performed.

RESULTS:

Overall 287 patients were successfully treated with methotrexate for a success rate of 90.1%. Six patients electively withdrew and requested surgery within 1 week of starting therapy. Excluding withdrawals the overall success rate was 92.9%. Ten patients with an ectopic pregnancy > 3.5 cm but < or = 4 cm in size were treated for a 90% success rate. Forty-four patients with positive ectopic cardiac activity were treated with an 87.5% success rate.

CONCLUSIONS:

This large series indicates that single-dose intramuscular methotrexate for treatment of ectopic pregnancy is associated with an excellent overall success rate.

PMID:
9662322
DOI:
10.1016/s0002-9378(98)70343-6
[Indexed for MEDLINE]

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