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Keio J Med. 1998 Jun;47(2):73-7.

HMGI family proteins: architectural transcription factors in mammalian development and cancer.

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Department of Biochemistry, UMDNJ-Robert Wood Johnson Medical School 08854-5635, USA.


The HMGI proteins, a subfamily of the high mobility group (HMG) proteins, play an important role in the regulation of gene expression. They bind to AT-rich DNA sequences and alter DNA conformation to modulate the binding affinity of transcription factors to their cognate sites. They are expressed almost exclusively during embryogenesis and Hmgi-c null mice have the mouse pygmy phenotype. Studies have revealed the disruption of HMGI family genes in a variety of mesenchymal-derived benign tumors. Therefore, the HMGI genes function in the coordination of cell proliferation and differentiation during mammalian development.

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