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Neurosci Lett. 1998 May 15;247(2-3):95-8.

Imidazoline receptor proteins in brains of patients with Alzheimer's disease.

Author information

1
Department of Psychiatry, Faculty of Medicine, University of Geneva, H.U.G., Chêne-Bourg, Switzerland.

Abstract

Imidazoline receptors (29/30- and 45-kDa proteins) were quantitated in postmortem brains of patients with Alzheimer's disease (AD) by using immunoblotting techniques and a specific antiserum. Increased levels of the 29/30-kDa protein (30%), 45-kDa protein (36%) and glial fibrillary acidic protein (88%) were found in the frontal cortex of AD patients. These findings are in line with the reported higher density of imidazoline receptors labelled by [3H]idazoxan in AD brains, suggesting that these imidazoline receptor proteins are related to the I2-imidazoline receptor located in mitochondria of glial (astrocyte) cells.

PMID:
9655601
[Indexed for MEDLINE]

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