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Protein Sci. 1998 Jun;7(6):1477-80.

Structure and distribution of pentapeptide repeats in bacteria.

Author information

1
Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom. agb@sanger.ac.uk

Abstract

We report the discovery of a novel family of proteins, each member contains tandem pentapeptide (five residue) repeats, described by the motif A(D/N)LXX. Members of this family are both membrane bound and cytoplasmic. The function of these repeats is uncertain, but they may have a targeting or structural function rather than enzymatic activity. This family is most common in cyanobacteria, suggesting a function related to cyanobacterial-specific metabolism. Although no experimental information is available for the structure of this family, it is predicted that the tandem pentapeptide repeats will form a right-handed beta-helical structure. A structural model of the pentapeptide repeats is presented.

PMID:
9655353
PMCID:
PMC2144021
DOI:
10.1002/pro.5560070625
[Indexed for MEDLINE]
Free PMC Article

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