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Eur J Biochem. 1998 May 1;253(3):531-44.

Regulation of translation initiation factors by signal transduction.

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Utrecht University, Department of Molecular Cell Biology, The Netherlands.


Regulation of eukaryotic translation initiation is a process that requires collaboration between multiple proteins. The cap-binding factor eukaryotic initiation factor (eIF)4E, its binding protein 4E-BP1, and the guanine-nucleotide-exchange factor eIF2B play important roles in the regulation of the rate of protein synthesis. This review describes the regulation of the activity of these three proteins and the signal-transduction pathways involved therein.

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