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Int J Dev Biol. 1998;42(3):311-5.

Compartment boundaries: where, why and how?

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National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom.


In the 1960's, Garcia Bellido and colleagues uncovered the existence of developmental compartments in Drosophila. This observation has had a lasting impact on our understanding of developmental mechanisms in flies and vertebrates. Here, I review the work that demonstrated the existence of compartments. I then conjecture on why compartments exist and review the roles of various gene products in the maintenance of compartment boundaries.

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