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Br J Obstet Gynaecol. 1998 Jun;105(6):656-60.

Biochemical modifications of human whole saliva induced by pregnancy.

Author information

1
Istituto di Biochimica, Università degli Studi di Ancona, Italy.

Abstract

OBJECTIVE:

To assess human unstimulated whole saliva components during pregnancy, to determine the relation, if any, between pregnancy and oral health, particularly total protein concentration, alpha-amylase activity, sialic acid content and calcium and phosphate concentrations were evaluated.

DESIGN:

Cross-sectional study.

PARTICIPANTS:

Forty-five healthy primigravid women; 15 nonpregnant women acted as controls.

RESULTS:

1. A higher total protein content at 10 and 21 weeks of gestation with respect to the controls and to pregnant women at 40 weeks; 2. a higher alpha-amylase activity at 10 and 21 weeks of gestation compared with the controls and to pregnant women at 40 weeks; 3. an increased sialic acid content at 21 and 40 weeks; 4. decreased calcium and phosphorus concentrations at 21 and 40 weeks of gestation.

CONCLUSIONS:

Pregnancy modifies saliva composition. This could play a pivotal role in the incidence of pregnancy-induced dental caries.

PMID:
9647157
[Indexed for MEDLINE]

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