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Pleckstrin homology domains: a common fold with diverse functions.

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1
Department of Anesthesiology, State University of New York at Stony Brook 11794, USA. rebecchi@epo.hsc.sunysb.edu

Abstract

Pleckstrin homology (PH) motifs are approximately 100 amino-acid residues long and have been identified in nearly 100 different eukaryotic proteins, many of which participate in cell signaling and cytoskeletal regulation. Despite minimal sequence homology, the three-dimensional structures are remarkably conserved. This review gives an overview of the PH domain architecture and examines the best-studied examples in an attempt to understand their function.

[Indexed for MEDLINE]

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