Goodpasture's Disease is an explosive multisystem disease presenting initially as a pulmonary-renal syndrome. There is often little margin for error in making an early correct diagnosis to avoid respiratory and renal failure. Complications of invasive diagnostic testing and aggressive immunosuppressive treatment often lead to other organ dysfunction due to infection, hemodynamic disturbances, fluid and electrolyte challenges, and nutritional deficiency. Artificial organ therapy is often needed for pulmonary and renal support, for immunomodulation, and for nutritional replacement. The outcome is often considered satisfactory if the patient survives the acute presentation. Persistent organ failure is quite often the case, especially renal failure. Quality of life is often improved if there is subsequent renal transplantation. By then the patient may be considered "cured". Two cases are described below, contrasting young and elderly white females both in previous good health who developed rapid onset of Goodpasture's disease. One was cured after transplantation, and one was cured without transplantation. The severity of the renal involvement was the same for both patients. Cure of Goodpasture's Disease in the native kidneys is uncommon; a review of the literature is provided.