Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Biochem Sci. 1998 Jun;23(6):213-6.

Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway.

Author information

1
Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS, INSERM, ULP, Strasbourg, France.

Abstract

The Ets family of transcription factors includes nuclear phosphoproteins that are involved in cell proliferation, differentiation and oncogenic transformation. The family is defined by a conserved DNA-binding domain (the ETS-DBD), which forms a highly conserved, winged, helix-turn-helix structural motif. As targets of the Ras-MAPK signaling pathway, Ets proteins function as critical nuclear integrators of ubiquitous signaling cascades. To direct signals to specific target genes, Ets proteins interact with (other) transcription factors that promote the binding of Ets proteins to composite Ras-responsive elements.

PMID:
9644975
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center