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Zh Vyssh Nerv Deiat Im I P Pavlova. 1998 Mar-Apr;48(2):291-5.

[The initial level of motor activity determines the directivity of the motor effect of apomorphine].

[Article in Russian]

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Bekhterev Psychoneurological Research Institute, St.-Petersburg.


In male mice of BALB/c and SHR strains with the highest base level of locomotion and rearings apomorphine (5 mg/kg) decreased these forms of motor activity while in C57BL/6 mice with the lowest base level of motor activity apomorphine increased it. In mice of C57BR and C3H/A strains with intermediate base level there was a tendency for an increase in activity. Extinction of exploratory motor activity in BALB/c as a result of four consecutive testings in the same experimental chamber with hourly intervals induced a decrease in activity of the animals by half. Being injected against this background the same dose of apomorphine (5 mg/kg) twice increased locomotion and rearings in these mice.

[Indexed for MEDLINE]

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