Format

Send to

Choose Destination
J Nat Prod. 1998 Jun 26;61(6):791-5.

Epolones: novel sesquiterpene-tropolones from fungus OS-F69284 that induce erythropoietin in human cells.

Author information

1
MYCOsearch, a subsidiary of OSI Pharmaceuticals, 4727 University Drive, Suite 400, Durham, North Carolina 27707, USA.

Abstract

In the course of our screening for small molecule modulators of erythropoietin gene expression, two novel sesquiterpene tropolones and pycnidone were isolated from a culture of OS-F69284 (ATCC 74390). Their structures were elucidated by extensive 1H and 13C NMR spectroscopic studies and chemical reactions. These compounds induced erythropoietin gene expression 5-fold at a concentration of 1-1.6 microM.

PMID:
9644066
DOI:
10.1021/np9800506
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for American Chemical Society
Loading ...
Support Center