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Lancet. 1998 May 2;351(9112):1317-9.

Bronchodilator S-nitrosothiol deficiency in asthmatic respiratory failure.

Author information

1
Pulmonary Division, Department of Pediatrics, Naval Medical Center, San Diego, CA, USA. bmg3g@virginia.edu

Abstract

BACKGROUND:

Nitric oxide (NO) gas concentrations are high in the expired air of individuals with asthma, but not consistently so in the expired air of people with pneumonia. S-nitrosothiols are naturally occurring bronchodilators, the concentrations of which are raised in the airways of patients with pneumonia. Airway S-nitrosothiols have not been studied in asthma.

METHODS:

Tracheal S-nitrosothiol concentrations from eight asthmatic children in respiratory failure were compared with those of 21 children undergoing elective surgery.

RESULTS:

Mean S-nitrosothiol concentrations in asthmatic children were lower than in normal children (65 [SD 45] nmol/L vs 502 [SD 429] nmol/L) and did not vary with inspired oxygen concentration or airway thiol concentration.

INTERPRETATION:

Severe asthma is associated with low concentrations of airway S-nitrosothiols. This is the first reported deficiency of an endogenous bronchodilator in the human asthmatic airway lining fluid. We suggest that S-nitrosothiol metabolism may be a target for the development of new asthma therapies.

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PMID:
9643794
DOI:
10.1016/S0140-6736(97)07485-0
[Indexed for MEDLINE]

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