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J Mol Biol. 1998 Jun 19;279(4):921-8.

Solution structure and dynamics of the bioactive retroviral M domain from Rous sarcoma virus.

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  • 1The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.


A biologically active construct of the retroviral M domain from the avian Rous sarcoma virus is defined and its solution structure described. This M domain is fully active in budding and infectivity without myristylation. In spite of a sequence homology level that suggests no relationship among M domains and the family of matrix proteins in mammalian retroviruses, the conserved structural elements of a central core allow an M domain sequence motif to be described for all retroviruses. The surface of the M domain has a highly clustered positive patch comprised of sequentially distant residues. An analysis of the backbone dynamics, incorporating rotational anisotropy, is used to estimate the thermodynamics of proposed domain oligomerization.

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