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Curr Opin Cell Biol. 1998 Jun;10(3):361-5.

Locus control regions, chromatin activation and transcription.

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Erasmus University, Faculty of Medicine, Department of Cell Biology and Genetics, Rotterdam, The Netherlands.


The past year has seen interesting advances in our understanding of the action of locus control regions. For the first time, the chromosomal distance was described in detail as a parameter in positive/negative regulation of transcription via gene competition. A number of publications have also described negative regulatory elements which restrict the action of locus control regions and other regulatory regions to specific genes and/or specific tissues. The emerging picture indicates that several very different types of negative regulation ensure that transcriptional activation occurs only in the appropriate cells.

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