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Curr Opin Cell Biol. 1998 Jun;10(3):361-5.

Locus control regions, chromatin activation and transcription.

Author information

1
Erasmus University, Faculty of Medicine, Department of Cell Biology and Genetics, Rotterdam, The Netherlands. fraser@ch1.fgg.eur.nl

Abstract

The past year has seen interesting advances in our understanding of the action of locus control regions. For the first time, the chromosomal distance was described in detail as a parameter in positive/negative regulation of transcription via gene competition. A number of publications have also described negative regulatory elements which restrict the action of locus control regions and other regulatory regions to specific genes and/or specific tissues. The emerging picture indicates that several very different types of negative regulation ensure that transcriptional activation occurs only in the appropriate cells.

PMID:
9640537
DOI:
10.1016/s0955-0674(98)80012-4
[Indexed for MEDLINE]

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