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Curr Opin Cell Biol. 1998 Jun;10(3):311-6.

DNA mismatch repair and cancer.

Author information

1
Department of Genetics, University of Wisconsin-Madison 53706, USA. taprolla@facstaff.wisc.edu

Abstract

Mutations in DNA mismatch repair (MMR) genes have been associated with hereditary nonpolyposis colorectal cancer. Studies in bacteria, yeast and mammals suggest that the basic components of the MMR system are evolutionarily conserved, but studies in eukaryotes also imply novel functions for MMR proteins. Recent results suggest that mutations in MMR genes lead to tumorigenesis in mice, but DNA replication errors appear to be insufficient to initiate intestinal tumorigenesis in this model system. Additionally, MMR-deficient cell lines display a mutator phenotype and resistance to several cytotoxic agents, including compounds widely used in cancer chemotherapy.

PMID:
9640530
DOI:
10.1016/s0955-0674(98)80005-7
[Indexed for MEDLINE]

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