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Curr Opin Immunol. 1998 Jun;10(3):353-9.

The regulation and roles of Rel/NF-kappa B transcription factors during lymphocyte activation.

Author information

1
Immunology Division, Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia. georndakis@wehi.edu.au

Abstract

The activation of B and T cells by a wide range of stimuli can rapidly induce specific gene expression via a mechanism that promotes the nuclear translocation of different Rel/nuclear factor-kappa B (NF-kappa B) transcription factors which are normally resident in the cytoplasm. Recent findings highlight the crucial roles of specific Rel/NF-kappa B family members in the processes of cell division, apoptosis and differentiation that accompany lymphocyte activation.

PMID:
9638373
DOI:
10.1016/s0952-7915(98)80175-1
[Indexed for MEDLINE]

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