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J Rheumatol. 1998 Jun;25(6):1232-4.

Association of primary antiphospholipid syndrome with inherited activated protein C resistance.

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Institute of Clinical Medicine, Rheumatology Unit, Faculty of Medicine, 2nd University of Naples, Napoli, Italy.


A 65-year-old man had had arterial thromboses of the lower limbs and cerebral region for several years; tests revealed anticardiolipin, antiphosphatidylserine, anti-beta2-glycoprotein I antibodies, and lupus anticoagulant. As well, both phenotypic and genotypic resistance to activated protein C was found. Antiphospholipid antibodies have been reported to interfere in different ways with the functions of protein C; in our patient the simultaneous existence of inherited resistance to activated protein C could account for the thrombophilic status underlying the diffuse and serious arterial thromboses.

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