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Cell. 1998 May 29;93(5):767-77.

Wingless repression of Drosophila frizzled 2 expression shapes the Wingless morphogen gradient in the wing.

Author information

1
Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University Medical Center, California 94305, USA.

Abstract

In Drosophila wing imaginal discs, the Wingless (Wg) protein acts as a morphogen, emanating from the dorsal/ventral (D/V) boundary of the disc to directly define cell identities along the D/V axis at short and long range. Here, we show that high levels of a Wg receptor, Drosophila frizzled 2 (Dfz2), stabilize Wg, allowing it to reach cells far from its site of synthesis. Wg signaling represses Dfz2 expression, creating a gradient of decreasing Wg stability moving toward the D/V boundary. This repression of Dfz2 is crucial for the normal shape of Wg morphogen gradient as well as the response of cells to the Wg signal. In contrast to other ligand-receptor relationships where the receptor limits diffusion of the ligand, Dfz2 broadens the range of Wg action by protecting it from degradation.

PMID:
9630221
DOI:
10.1016/s0092-8674(00)81438-5
[Indexed for MEDLINE]
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