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Ann Neurol. 1998 Jun;43(6):826-8.

Codon 219 Lys allele of PRNP is not found in sporadic Creutzfeldt-Jakob disease.

Author information

1
Department of Neurological Science, Tohoku University School of Medicine, Sendai, Japan.

Abstract

The polymorphism at codon 219 of the prion protein gene (PRNP) was found in the general Japanese population with 6% allele frequency. Herein, we examined 85 cases of sporadic Creutzfeldt-Jakob disease (CJD) for the codon 219 polymorphism. The codon 219Glu/Lys heterozygous polymorphism was not found in these CJD cases. In addition, we examined 43 patients with dementia of non-CJD origin, and 4 were found to have the codon 219Glu/Lys heterozygous polymorphism with a similar allele frequency as in the general population. Thus, the codon 219Glu/Lys heterozygous polymorphism might be uniquely excluded from sporadic CJD.

PMID:
9629853
DOI:
10.1002/ana.410430618
[Indexed for MEDLINE]

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