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Biol Signals Recept. 1998 Mar-Apr;7(2):125-35.

Lipid modifications and membrane targeting of G alpha.

Author information

1
Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA. P_Wedegaertner@ac.jc.tju.edu

Abstract

G protein alpha-subunits (G alpha) undergo palmitoylation and/or myristoylation. This review will focus on new insights into the function and regulation of these fatty acid modifications of G alpha. Most importantly, I will examine lipid modifications of G alpha in the context of a two-signal model for membrane attachment, discuss recent advances in the identification of palmitoyl transferases, and highlight several controversial issues in this field.

PMID:
9629464
DOI:
10.1159/000014538
[Indexed for MEDLINE]

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