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Ophthalmology. 1998 Jun;105(6):1091-8.

Cavitary melanoma of the ciliary body. A study of eight cases.

Author information

1
Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Abstract

PURPOSE:

The authors present the unique clinical features of cavitary uveal melanoma.

DESIGN:

Retrospective chart review.

PARTICIPANTS:

Eight patients with cavitary uveal melanoma.

MAIN OUTCOME MEASURES:

The clinical, ultrasonographic, and histopathologic features of eight patients with cavitary melanoma of the ciliary body were studied.

RESULTS:

In all eyes there was a brown ciliary body mass that blocked transmission of light on trans-scleral transillumination. Ocular ultrasonography revealed a large, single hollow cavity (unilocular "pseudocyst") in five cases and multiple hollow cavities (multilocular "pseudocyst") in three cases. The cavity occupied a mean of 55% of the entire mass thickness (range, 31%-79%). In five cases, a basal uveal mass was noted on ultrasonography. Four patients underwent tumor resection; one had enucleation, and three had 125I radioactive plaque treatment. In the five cases confirmed histopathologically, the cavitation was empty, contained erythrocytes, serous fluid, and/or pigment-laden macrophages. In no case was the cavity lined by necrotic tumor, endothelial cells, or epithelial cells.

CONCLUSION:

Ciliary body melanoma can develop an intralesional cavity resembling an intraocular cyst. The presence of a solid mass at the base and a thick wall surrounding the cavity can assist in the differentiation of cavitary melanoma from benign cyst.

PMID:
9627662
DOI:
10.1016/S0161-6420(98)96013-4
[Indexed for MEDLINE]

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