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Hybridoma. 1998 Apr;17(2):175-83.

Production and characterization of monoclonal antibodies to the catenin p120ctn.

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Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.


This report describes the generation and characterization of a panel of monoclonal antibodies (MAb) to the catenin p120ctn. p120ctn (formerly p120cas) is a cadherin-binding protein with structural similarity to the classical catenins beta-catenin and plakoglobin. It was originally identified as a prominent Src substrate and subsequently as a substrate for the Platelet Derived Growth Factor (PDGF), Epidermal Growth Factor (EGF), and Colony Stimulating Factor-1 (CSF-1) receptor tyrosine kinases. To facilitate further study of p120 function, we have generated novel MAbs to both the N- and C-terminal ends of p120 and compared them to previously described antibodies to these regions.

[Indexed for MEDLINE]

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