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Antimicrob Agents Chemother. 1998 Jun;42(6):1488-92.

Efficacies of zinc-finger-active drugs against Giardia lamblia.

Author information

1
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. tnash@atals.niaid.nih.gov

Abstract

Twenty-nine of 34 (85%) Zn-finger-active compounds at 300 microM or less inhibited the growth of Giardia lamblia. The most active compound, disulfiram (Antabuse), was cidal at 1.23 +/- 0.32 microM. In the adult mouse model, significant in vivo activity was demonstrated by increased cure rates and decreased parasite burdens.

PMID:
9624499
PMCID:
PMC105627
[Indexed for MEDLINE]
Free PMC Article

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