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J Hum Genet. 1998;43(2):132-4.

Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene.

Author information

1
Laboratory of Molecular Medicine, University of Tokyo, Japan.

Abstract

Activins, members of a family of proteins that includes transforming growth factor-beta (TGF-beta), are gonadal polypeptide hormones that stimulate secretion of follicle-stimulating hormone (FSH). During large-scale sequencing analysis of a 1.2-Mb fragment of human genomic DNA on 3p22-p21.3, we found the gene encoding activin receptor type IIB (hActR-IIB). Comparison of its reported cDNA sequence with this genomic sequence showed that the hActR-IIB gene consists of 11 exons and spans about 30 kb of genomic DNA.

PMID:
9621519
DOI:
10.1007/s100380050054
[Indexed for MEDLINE]

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