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Emerg Infect Dis. 1998 Apr-Jun;4(2):195-209.

Multidrug-resistant Mycobacterium tuberculosis: molecular perspectives.

Author information

1
Department of Microbiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India. rattan@medinst.ernet.in

Abstract

Multidrug-resistant strains of Mycobacterium tuberculosis seriously threaten tuberculosis (TB) control and prevention efforts. Molecular studies of the mechanism of action of antitubercular drugs have elucidated the genetic basis of drug resistance in M. tuberculosis. Drug resistance in M. tuberculosis is attributed primarily to the accumulation of mutations in the drug target genes; these mutations lead either to an altered target (e.g., RNA polymerase and catalase-peroxidase in rifampicin and isoniazid resistance, respectively) or to a change in titration of the drug (e.g., InhA in isoniazid resistance). Development of specific mechanism-based inhibitors and techniques to rapidly detect multidrug resistance will require further studies addressing the drug and drug-target interaction.

PMID:
9621190
PMCID:
PMC2640153
DOI:
10.3201/eid0402.980207
[Indexed for MEDLINE]
Free PMC Article

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