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Cytokine Growth Factor Rev. 1997 Dec;8(4):267-92.

TGF-beta in the central nervous system: potential roles in ischemic injury and neurodegenerative diseases.

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Protein and Cell Therapeutics Development Group, Genzyme Tissue Repair Division, Genzyme Corporation, Framingham, MA 01701-9322, USA.


The Transforming Growth Factor-betas (TGF-beta) are a group of multifunctional proteins whose cellular sites of production and action are widely distributed throughout the body, including the central nervous system (CNS). Within the CNS, various isoforms of TGF-beta are produced by both glial and neural cells. When evaluated in either cell culture or in vivo models, the various isoforms of TGF-beta have been shown to have potent effects on the proliferation, function, or survival of both neurons and all three glial cell types, astrocytes, microglia and oligodendrocytes. TGF-beta has also been shown to play a role in several forms of acute CNS pathology including ischemia, excitotoxicity and several forms of neurodegenerative diseases including multiple sclerosis, Parkinson's disease, AIDS dementia and Alzheimer's disease.

[Indexed for MEDLINE]

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