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Int J Food Microbiol. 1998 Apr 14;40(3):177-83.

Antimicrobial spectrum and target site of D-3-phenyllactic acid.

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Laboratoire de Microbiologie Alimentaire, Institut de Recherche en Biologie Appliquée, Université de Caen, France.


Geotrichum candidum excretes D-3-phenyllactic acid, which inhibits the growth of Listeria monocytogenes. It was found to inhibit a range of gram-positive bacteria found in humans and foodstuffs, such as Staphylococcus aureus and Enterococcus faecalis, and gram-negative bacteria from humans, such as Providencia stuartii and Klebsiella oxytoca. Scanning electron microscope studies on the effect of D-3-phenyllactic acid on L. monocytogenes showed that it caused changes in bacterial behavior and structure. The bacteria formed aggregates and secreted polysaccharides; their cell walls lost their rigidity, causing the cells to swell. Finally the bacteria broke down completely and the cells disintegrate.

[Indexed for MEDLINE]

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