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Semin Immunol. 1998 Apr;10(2):143-53.

The role of E-proteins in B- and T-lymphocyte development.

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Department of Biology, University of California, San Diego, La Jolla 92093, USA.


Department of lymphocytes from hematopoietic stem cells is controlled, in part, by the activity of transcriptional regulatory proteins. In particular, one class of helix-loop-helix proteins, termed E-proteins, have been implicated in the regulation of gene expression during B-cell development. Recent analysis of gene-targeted mice has allowed a direct assessment of the functional roles of several E-protein family members in hematopoiesis. In this review we describe the defects in B- and T-lymphocyte development in mice carrying targeted mutations in the E-protein genes and discuss our current understanding of the role of these proteins in lymphoid development.

[Indexed for MEDLINE]

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