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Eur Cytokine Netw. 1998 Mar;9(1):69-73.

Molecular cloning and sequencing of the rat interleukin-12 p40 gene.

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Centre d'Immunologie et de Biologie Parasitaire, INSERM U. 167, Institut Pasteur, Lille, France.


The nucleotide sequences containing the rat interleukin-12 p40 gene was determined. Sequencing revealed the presence of six exons and five introns. Analysis of the 5' non-coding region showed the presence of several possible sites involved in cytokine gene regulation at the transcriptional level. Comparison of the deduced amino acid sequence of rat IL-12 p40 with that of the mouse and of human p40, showed 92% and 65% identity respectively.

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