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Mol Med Today. 1998 May;4(5):196-200.

Do endogenous cannabinoids contribute to HIV-mediated immune failure?

Author information

1
National Laboratory for the Genetics of Israeli Populations, Sackler Faculty of Medicine, Tel-Aviv University, Israel. gurwitz@post.tau.ac.il

Abstract

The failure of the immune system to mount a successful attack on the human immunodeficiency virus (HIV) is an old enigma for AIDS research. The high mutational capacity of HIV, which unremittingly confuses the immune system, is a major factor in immune failure. But this alone cannot fully explain the certain and inescapable failure of the immune system, leading to full-blown AIDS. Here, we propose the hypothesis that endogenous cannabinoids, derived mostly from macrophages, might participate in the general failure of the immune system in HIV-infected individuals.

PMID:
9612798
DOI:
10.1016/s1357-4310(98)01254-4
[Indexed for MEDLINE]

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